Risk factors of central diabetes insipidus after transnasal adenomectomy

Background : At present, surgical intervention is a major treatment strategy for pituitary adenomas. It commonly complicated with water and electrolyte imbalance. The prevalence of post-surgical central diabetes insipidus (CDI) may amount to 30%; however, its risk factors have not been established. Aim To assess the rates nosological distribution CDI after transnasal adenomectomy identify factors. Materials methods This retrospective study included 96 patients aged 20 65 years (median [Q1; Q3] 43 [34.5; 53.5]), who had in 2010–2011 due Cushing's disease, acromegaly, prolactinoma, non-functioning adenoma. All underwent clinical examination laboratory work-up before surgery. Their course was assessed 5 7 years. Depending on identified manifestations, were categorized into permanent (n=15) transient (n=34); 47 no CDI. Results disease (odds ratio (OR) 6.1, 95% confidence interval (CI) 2.3–16.1), secondary adrenal insufficiency (OR 6.8, CI 2.6– 18.3) adrenocorticotropic hormone levels of˂15.8 pg/mL 5.0, 1.9–13.5), microadenoma 4.5, 1.7–11.5) promote postoperative CDI, whereas macroadenoma decrease this 0.2, 0.1–0.5). also more common hypothyroidism, cortisol level of˂200 nmol/L, adenoma's volume at magnetic resonance imaging of<0.83 cm3 trend rare acromegaly loss tropic hormones surgery as well. No significant but it could be often associated absence any adenoma injury during less frequent macroadenomas level. Conclusion: proportion 16% (95% 9–24), that form 35% 25–45). ˂0.83 Conclusion microadenoma, development increase probability does risk.